By Patrick Stoney
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You’ve worked hard to purify your gene of interest, get it into your plasmid backbone, and zap the mixture of DNA into cells. Unfortunately, not every cell successfully takes up plasmid DNA. Among those that do, some now have plasmids that contain your gene of interest, but ...
The aim of behavioral neuroscience is to define brain areas that are linked to a certain behavior. It is a very old branch of science, dating back several hundred years, with historical ties to psychology and philosophy (the mind-body problem). Because of the availability of ...
This post was contributed by Jacob Lazarus, a postdoctoral researcher at Harvard. There’s an astounding number of ways to create chromosomal mutations in bacteria, so many that it may be difficult to decide which path to take. A quick and easy way to introduce a mutation in the ...
This post was contributed by Katherine Rogers, a postdoctoral researcher at the Friedrich Miescher Lab of the Max Planck Society. Zebrafish (Danio rerio) have been used since the 1930’s in a range of biological studies, including investigations into environmental pollutants and ...
This post was contributed by Magdalena Julkowska, a postdoctoral researcher at KAUST, Saudi Arabia. From the perspective of an author submitting a paper, the peer-review seems like another dragon to slay on the way to publish your work in a scientific journal. The peer-review is ...
In Part 1 of our mouse modeling blog series, we covered techniques that can be used to introduce genetic modifications into mouse embryos. But once you generate a growing colony of genetically engineered mice, what can you do? In this post, we’ll cover why and how to cross mice ...
Feelings of delight associated with the brain’s reward circuits are generally linked to dopamine (DA), a well-known reward chemical and neurotransmitter. But aside from DA’s famous role as the “happy hormone,” it’s also involved in reinforcement learning, decision making, and ...
