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Antibodies 101: Introduction to Antibodies

Posted by Aliyah Weinstein on January 19, 2021

You may have heard the term antibody tossed around in the news or in the lab. But what exactly is an antibody, and how is a component of the immune system useful as a research reagent? Let’s find out!

What is an antibody?

Antibodies, also known as immunoglobulins, are ~150 kDa, Y-shaped proteins that are both a natural part of the immune system and a tool that can be used for a variety of research applications. Within the immune system, antibodies are produced by B cells. They bind to proteins on the surface of extracellular pathogens such as parasites or microbes, or to proteins expressed on the surface of cells that have been infected with a microbe, to trigger immune cascades that clear these infections. Anything that generates an antibody response in the immune system is referred to as an antigen.

The ability of antibodies to bind proteins is useful for research applications as well because they allow scientists to target specific proteins they’re interested in. Once a protein is targeted with an antibody, you can visualize the protein via fluorescence or chemiluminescence, precipitate the protein out of solution, or isolate cells expressing this protein. Read on to learn more about antibodies and how to use them in the lab!

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Topics: Other, Antibodies

Congratulations, Deck The Lab winners!

Posted by Aliyah Weinstein on January 14, 2021

2020 was a year like no other, with many scientists working remotely instead of from the lab. Nonetheless, Addgene’s annual Deck the Lab competition drew upon the creativity of the community, who delivered impressive science-themed holiday decorations yet again. This year, we had two different categories: one for decorations in the lab, and one for home.

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Topics: Fun at Addgene, Addgene News

Networking Follow-up: I Met a Person. Now What?

Posted by Joanne Kamens on January 12, 2021

Relationships need nurturing. Perhaps you’ve met someone interesting at an event. Or, perhaps you have a colleague who seems fun and helpful who you’d like to get to know better. Networking is not about how many contacts you have; it’s about building genuine relationships with people you care about knowing. How do you follow up with new connections and build the relationship in a non-awkward way? 

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Topics: Science Careers, Networking

Hot Plasmids and Viral Preps - January 2021

Posted by Various Addgenies on January 05, 2021

Every few months we highlight a subset of the new plasmids and viral preps in the repository through our hot plasmids articles. These articles provide brief summaries of recent plasmid deposits and we hope they'll make it easier for you to find and use the plasmids you need. If you'd ever like to write about a recent plasmid deposit please sign up here

Here's what you'll find in this post:

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Topics: Hot Plasmids, Plasmids, Other

Addgene's Top Blog Posts from 2020

Posted by Jennifer Tsang on December 29, 2020

Good bye 2020! What a year it has been for all of us. As we eagerly await 2021, we've looked back on the year would like to highlight some of the top articles from the Addgene blog this year. Spoiler alert: many of the top 10 posts from this year were influenced by COVID-19 and our new cloning grade DNA service.

We've had 11 blog posts on COVID-19 featuring plasmid tools from depositors who quickly shared their reagents: detection methods, synthetic nanobodies, SARS-CoV-2 protein expression, and more. We also highlighted reagent repositories and other collaborative efforts in the scientific community to speed COVID-19 research. With the COVID-19 pandemic, we saw the need to expand reagent sharing even broader and began working with tech transfer offices to make reagents available to scientists in both academia and industry.

This year, we also launched the cloning grade DNA service. This service features 210 plasmids: empty backbones, fluorescent protein tags, SARS-CoV-2 plasmids, etc. It is our hope that by providing cloning grade DNA to you, we'd save you days of time so that you can begin your cloning experiment right away.

And without further ado, here are the top ten!

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Topics: Inside Addgene, Addgene News

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