By Chonnettia Jones
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The genome-editing tool CRISPR is famously RNA-guided... except when it’s not. Turns out, carefully designed RNA-DNA hybrid strands work just as well—or maybe even better—at guiding Cas nucleases to specific genomic targets.
Throughout its 20-year history, Addgene’s mission has been to empower scientists to advance discoveries by reducing barriers, facilitating access to high-quality research materials, tools, and resources, while also fostering scientific collaboration. The first request through ...
Who doesn’t love a library? A traditional library might contain thousands or millions of different books. Addgene’s pooled libraries are a little different: each is a collection of plasmids that share the same backbone and differ only in a small region. This makes them useful ...
Every few months we highlight some of the new plasmids, antibodies, viral preps, and more in the repository through our Hot Plasmids articles.
This post was written by Professor Mark Howarth, investigator at the University of Cambridge. His research focuses on protein innovations for therapeutic and vaccine design. We all want tools that expand what we can achieve, but are simple to pick up and work well the first ...
Studying proteins in their natural context is one of the biggest challenges in biology. From tumor suppressors to growth factors, some of the most clinically-relevant proteins are also the hardest to study. One common strategy is protein overexpression — boosting levels so ...
It was huge news earlier this year: the first patient in the world, an infant, was successfully treated with a CRISPR gene editing therapy personalized to his genetic mutation. “Baby KJ” was diagnosed with a rare and dangerous metabolic disease shortly after his birth. Within a ...
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