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Hot Plasmids December 2018 - C. elegans RNAi, TurboID, detecting viral outbreaks, and protein binding specificity tools

Posted by Various Addgenies on Dec 6, 2018 8:34:06 AM

Every few months we highlight a subset of the new plasmids in the repository through our hot plasmids articles. These articles provide brief summaries of recent plasmid deposits and we hope they'll make it easier for you to find and use the plasmids you need. If you'd ever like to write about a recent plasmid deposit please sign up here

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Topics: Hot Plasmids

Winter is here and it's time to #DeckTheLab

Posted by Jennifer Tsang on Dec 4, 2018 9:01:57 AM

Winter is upon us and we’re getting into the holiday spirit here at Addgene. We’ve adorned our walls with snowflakes, put out some hot chocolate, and added some winter cheer to the lab.

Now it’s your turn! Show us your lab holiday decorations by participating in our annual #DeckTheLab contest. Get creative and build a pipette tip tree or go all out and create a massive wall mural. Snap a photo of your lab holiday decor and tag it with #DeckTheLab and @Addgene. This year, we’re opening up the contest to Twitter and Instagram.

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Topics: Fun, Inside Addgene

CRISPR-Cas14: a family of small DNA-targeting enzymes enabling high-fidelity SNP genotyping

Posted by Benoit Giquel on Nov 29, 2018 8:53:18 AM

Before being adapted by scientists to edit the genome of virtually any organisms on this planet, CRISPR-Cas systems were merely adaptive immune systems that provide bacteria protection against infectious agents. Several enzymes behind this immunity have already been discovered and studied but it is only the tip of the iceberg as it has been predicted that many others are still unknown.

In this quest to discover new and maybe more efficient Cas systems, Jennifer Doudna’s lab analyzed metagenomic datasets to try to determine whether simpler and maybe smaller Cas systems could exist in nature.

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Topics: CRISPR

Addgene-Seeding Labs plasmid grant round 3: microbial drug resistance and biofilms, antidiabetic plant components, visualizing brain injury - and a glowing robot fish

Posted by Various Addgenies on Nov 27, 2018 9:00:06 AM

By Susanna Bachle and Ina Ersing

Seeding Labs and Addgene collaborate to provide scientific resources, equipment, and plasmids to researchers in resource-limited settings. More specifically, the Addgene-Seeding Labs plasmid grant provide plasmids to these researchers. In the third round of the Addgene-Seeding Labs plasmid grant we are excited to introduce the 5 awardees and their research. These researchers span four continents and research diverse topics including microbiology, brain injury, drug discovery, and synthetic biology. Read on to learn more about the five awardees and their promising research projects.

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Topics: Seeding Labs

Unique and persistent IDs for improved reproducibility: Addgene now supports RRIDs and compact identifiers for all plasmids

Posted by Angela Abitua on Nov 20, 2018 3:17:00 PM

Have you ever found yourself frustrated reading through a paper to find that there is insufficient information about which reagents were used? Unambiguous identification of a reagent is crucial for reproducibility because mistakes in this can lead to wasted time or retractions.

Using a catalog number for identifying a reagent can be helpful, but it lacks context unless it links to a verified description of that reagent online. Furthermore, if the link between the catalog number and reagent description is lost (e.g. a supplier is bought out by another company and catalog number changes) the original identifier loses its meaning, making it difficult or impossible for researchers to track down that resource. A more long-term solution is the use of unique persistent identifiers (PIDs), a long-lasting way to identify and reference documents, files, or physical reagents.

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Topics: Reproducibility

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