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As 2025 closed, we received a request that perfectly embodies why Addgene exists: a researcher in Laos needed a unique set of plasmids to advance their research. Thanks to five different labs across the U.S. who deposited their plasmids with Addgene to share with the rest of the ...
The genome-editing tool CRISPR is famously RNA-guided... except when it’s not. Turns out, carefully designed RNA-DNA hybrid strands work just as well—or maybe even better—at guiding Cas nucleases to specific genomic targets.
Throughout its 20-year history, Addgene’s mission has been to empower scientists to advance discoveries by reducing barriers, facilitating access to high-quality research materials, tools, and resources, while also fostering scientific collaboration. The first request through ...
Who doesn’t love a library? A traditional library might contain thousands or millions of different books. Addgene’s pooled libraries are a little different: each is a collection of plasmids that share the same backbone and differ only in a small region. This makes them useful ...
Every few months we highlight some of the new plasmids, antibodies, viral preps, and more in the repository through our Hot Plasmids articles.
This post was written by Professor Mark Howarth, investigator at the University of Cambridge. His research focuses on protein innovations for therapeutic and vaccine design. We all want tools that expand what we can achieve, but are simple to pick up and work well the first ...
Studying proteins in their natural context is one of the biggest challenges in biology. From tumor suppressors to growth factors, some of the most clinically-relevant proteins are also the hardest to study. One common strategy is protein overexpression — boosting levels so ...
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