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Five Popular Model Organisms

Posted by Various Addgenies on Apr 11, 2019 8:39:27 AM

By Alyssa Cecchetelli and Lukas Morgan

Model organisms are vital tools used by researchers around the globe. These organisms share many genes with humans, are easily maintained in the lab, and have short generation times that make it easy to study the effects of genetic manipulations. In this blog post, we’ll cover five popular model organisms, but there are many more out there.

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Topics: Other, Organisms

The Breast Cancer Microenvironment: A Tumor’s Backstage Team

Posted by Guest Blogger on Jan 31, 2019 8:32:02 AM

This post was contributed by Bárbara Pinho, a science communicator at the Portuguese science museum "Fábrica Centro Ciência Viva" in Aveiro, Portugal.

If cancer was a musician, then metastasize is touring. But you know what a touring musician needs? A backstage team. Meet the microenvironment, a tumor’s backstage team.

Microenvironments are cellular regions with specialized structures. Tumors are surrounded by microenvironments and what encircles a disease is highly prone to affect it. While tumors may be the stars, there's plenty of action outside of tumor cells, and recent studies (Martins et al., 2018 and Xing et al., 2010) revealed precisely that for breast cancer.

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Topics: Cancer, Other

Natural or synthetic? How Addgene’s dataset reveals trends in biological innovation

Posted by Jennifer Tsang on Nov 8, 2018 10:47:22 AM

For the last 14 years, scientists have been coming to the Addgene website in search of plasmids. Now, scientists are beginning to see Addgene as a large data set. Addgene has over 65,000 plasmids in the repository, each verified by sequencing, which makes the repository a convenient source of sequence data.

A group of scientists from MIT tapped into this data to learn about trends in synthetic biology and DNA synthesis. They published their results in a paper in Nature Communications announcing a new bioinformatics tool that can predict whether a gene is natural or synthetic just by looking at its sequence.

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Topics: Synthetic Biology, Other

Starter Guide to induced Pluripotent Stem Cells (iPSCs) Part 2:  Reprogramming and Transdifferentiation

Posted by Guest Blogger on Nov 6, 2018 8:12:52 AM

This post was contributed by Kusumika (Kushi) Mukherjee.

The ultimate goal in the field of regenerative medicine is to replace lost or damaged cells. Here, I will discuss the two major processes by which an adult somatic cell is converted to a different cell type for regeneration and repair and situations where one process is favored over the other.

Visit Our Stem Cell Pages

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Topics: Stem Cells, Other

Starter guide to induced pluripotent stem cells (iPSCs) part 1:  A renaissance in regenerative medicine

Posted by Guest Blogger on Oct 30, 2018 9:04:26 AM

This post was contributed by Kusumika (Kushi) Mukherjee, editor of Trends in Pharmacological Sciences, a Cell Press reviews journal.

Stem cells are special types of cells that can develop or “differentiate” into more specialized cells with specific functions [1]. In many tissues, stem cells serve to replenish/replace damaged cells that no longer function adequately [1]. Stem cells’ ability to differentiate into multiple cell types makes them useful models for developmental processes and promising therapeutic tools. The two unique characteristics that define stem cells are:

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Topics: Stem Cells, Other

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