Deaminet 2026, held in Palm Springs in late January, brought together researchers studying deaminase enzymes across disciplines: from structural biologists resolving APOBEC proteins at atomic resolution, to cancer biologists dissecting mutational processes, to medical ...
These days, it hardly seems like we finish writing about one dual CRISPR-transposon system before another exciting new advance emerges! The programmability and targeting power of CRISPR combined with the large sequence capacity of transposons open whole new worlds to explore. ...
The versatility of CRISPR allows you to play with DNA in a number of ways, from small edits that change single base pairs, to chromosomal inversions and large deletions. Many of these methods rely on Cas9 or a derivative of Cas9, but the ever-expanding repertoire of CRISPR has ...
The hardest part of any revolutionary discovery, including CRISPR, is turning potential into impact. In molecular and cellular biology, this happens through the development of tools that exploit and expand our current knowledge. The Abudayyeh-Gootenberg lab (also called the ...
Originally published Jan 27, 2015 and last updated Dec 17, 2020. This post was contributed by Jordan Ward who is an assistant professor at the University of California, Santa Cruz. Emerging CRISPR/Cas9 editing technologies have transformed the palette of experiments possible in ...
This post was contributed by guest blogger, Leo Vo, a PhD candidate in the Sternberg Lab at Columbia University Medical Center. DNA transposons are ubiquitous genetic elements capable of spreading within and between genomes, and have been adapted for a wide variety of ...
This blog post was originally written by Caroline LaManna, published Mar 8, 2016. The updated and expanded version by Nyla Naim was published Sept 3, 2020. Scientists around the world have been making major improvements to CRISPR technology since its initial applications for ...
Originally published Dec 7, 2017 and updated Jul 2, 2020. Promoters may be the star of gene regulation, but enhancers and chromatin looping play important supporting roles. Enhancers are cis regulatory DNA sequences that, when bound by transcription factors, can increase a ...
