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No Llamas Required - Synthetic Nanobodies Against Membrane Proteins

Posted by Angela Abitua on Jun 18, 2020 9:15:00 AM

Nanobodies from camelids have gotten a lot of press for being a promising approach for treatment or prophylaxis of COVID-19. Researchers identified nanobodies that bind to coronavirus spike proteins (Wrapp et al., 2020), which sit on the surface of coronaviruses and enable the virus to enter host cells. To do this, they injected the spike protein from two different coronaviruses into a llama over several days and isolated special camelid antibodies that bind to the spike proteins in cell culture, and inhibit these viruses. 

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Topics: Other Plasmid Tools, Plasmids, COVID-19

Hot Plasmids - June 2020 - Barcoded CRISPR Library, Sparse Cell Labeling, Calcineurin Reporter, and DNA Staining Dye Alternative

Posted by Various Addgenies on Jun 2, 2020 9:15:00 AM

Every few months we highlight a subset of the new plasmids in the repository through our hot plasmids articles. These articles provide brief summaries of recent plasmid deposits and we hope they'll make it easier for you to find and use the plasmids you need. If you'd ever like to write about a recent plasmid deposit please sign up here

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Topics: Hot Plasmids, Other Plasmid Tools, Plasmids

Sharing Plasmids Globally for COVID-19 Research

Posted by Jennifer Tsang on Apr 30, 2020 9:15:00 AM

In the past few weeks, we’ve received over 2,600 COVID19 related plasmid requests. These plasmids have been heading to research labs in 43 countries.

COVID-19 research is happening fast and we’re glad to join these efforts and help scientists through plasmid sharing and more. These include plasmids that have been in the repository for many years, and new plasmids that scientists have deposited in the last several weeks. We've grown the collection of COVID-19 related plasmids to over 500 plasmids and our mission to accelerate research through sharing reagents has never been so important as scientists work around the clock to find solutions for COVID-19. Sharing speeds science.

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Topics: Other Plasmid Tools, Plasmids, COVID-19

Early Career Researcher Toolbox: Free Online Molecular Biology Tools

Posted by Beth Kenkel on Apr 14, 2020 9:15:00 AM

Primer design. Plasmid mapping. DNA sequence analysis. We all have our favorite tools for tackling these particular tasks, but they tend to be scattered about the internet. To help you keep your virtual molecular biology toolbox organized, today’s post features a list of free online molecular biology tools all in one place.

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Topics: Plasmid Cloning, Other Plasmid Tools, Plasmids, Early Career Researcher

Scientists Map the SARS-CoV-2-Human Interaction Network

Posted by Guest Blogger on Apr 9, 2020 9:15:00 AM

This post was contributed by Manon Eckhardt and Melanie Brewer from the QBI Coronavirus Research Group at UCSF.

It’s been only a few months since we all became acutely aware of the threat of SARS-CoV-2. Like many in the science community, we’ve been motivated to do anything and everything we can to help find a cure -- and quickly. Normally drug discovery is a process that would take years and millions, if not billions, of dollars, but by approaching it from a new direction, we hope to do it much faster.

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Topics: Other Plasmid Tools, Plasmids, COVID-19

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