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Originally published Nov 12, 2015 and last updated Aug 20, 2020. Cas9 can be used to modify any desired genomic target provided that (1) the sequence is unique compared to the rest of the genome and (2) the sequence is located just upstream of a Protospacer Adjacent Motif (PAM ...
Every few months we highlight a subset of the new plasmids and viral preps in the repository through our hot plasmids articles. These articles provide brief summaries of recent plasmid deposits and we hope they'll make it easier for you to find and use the plasmids you need. If ...
Hola! Que tal? My name is Brandon Solis, and I am a rising senior studying Sociology and Dance at Skidmore College. I was also Addgene’s Marketing Intern this summer! With the help of Project Onramp, I was able to gain access to an internship on the journey to full-time ...
So you have this awesome experiment you want to do, but it requires some AAV. You’ve never worked with AAV before, but you aren’t going to let that stop you. Where do you start? Turns out like all good experiments, making AAV starts with some plasmids. You just need three ...
Scientists need fast access to the tools required to study SARS-CoV-2, but with many academic research labs closed during the pandemic, it’s hard to get these reagents. However, when reagents have been made available through a repository, they remain accessible during these ...
Originally published Nov 30, 2017 and updated Jul 31, 2020. Cas13 enzymes are quickly becoming major players in the CRISPR field. Just a year after Feng Zhang’s lab identified Cas13a (C2c2) (Abudayyeh et al., 2016) as a RNA-targeting CRISPR enzyme, they adapted Cas13b for ...
Marc Zimmer’s recent book, The State of Science: What the Future Holds and the Scientists Making It Happen, is an exercise in restraint. The very first subheading in Chapter 1 asks “What is science?” That’s a very big question. Zimmer, a Professor of Chemistry at Connecticut ...
