By Susanna Stroik
Read More
Using AAV vectors in complex biological systems can be tricky at best, and downright infuriating at worst. While it is tempting to just dive right in and start injecting your virus, a successful AAV experiment starts with validation and optimization. Although there are different ...
Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. AAVs are non-pathogenic, do not integrate into the host genome, and can be ...
We often think about the brain’s function in terms of its regions. But equally important is the way the brain connects across these regions, a process driven by neurons. By studying how neurons are physically connected, we can begin to understand how the brain works. It’s kind ...
Viruses are the SUVs of molecular biology – they can deliver materials to specific destinations, haul a variety of cargo, and even handle a variety of terrains. They are, in fact, a choice delivery vector from basic science research all the way to clinical gene therapy. But how ...
Viruses have many negative associations: common colds, COVID-19, norovirus (the stomach flu), and many more. Their infectious nature allows them to easily deliver their “cargo” to target cells and organisms, and when that cargo is designed to make you sick…well, you feel it. But ...
Did you catch our April AAV webinar with Tim Miles, PhD, Director of the CLOVER Center at CalTech? If so, you may have submitted a question that didn’t get answered live - but he kindly took some time to address all your unanswered questions via text! (well, maybe not all of ...
This post was originally written by Tyler Ford in 2018. It was updated by guest blogger Abhi Aggarwal in 2022. Recent updates to iGluSnFR and SF-iGluSnFR have made it clear that it’s time to update our iGluSnFR post! Here, we look at the origins of the system and explore ...
