A New Generation of Adenine Base Editors Improves Editing in Primary Human Cells

By Susanna Bachle

Read More

Recent Posts

DETECTR-SHERLOCK_Blog_image
Workflow of phage-assisted evolution of base-editing activity. Fresh host cells contain Cas, mutated gIII, and mutagenesis plasmids. Phage infection delivers the deaminase plasmid. After mutagenesis, if the base editor is inactive, no pIII is produced, and the progeny phage are not infectious. If the base editor is active, however, pIII is produced and the progeny phage are infectious, allowing them to continue propagating.
New CRISPR plasmids at Addgene

Sharing science just got easier... Subscribe to our blog