New Optimized Genome-wide CRISPRko, CRISPRi, and CRISPRa Libraries

By Alyssa Cecchetelli

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Summary of the advantages of the new approach to genome-wide CRISPR screen design: Safe-targeting guides better control for dsDNA break toxicity by targeting Cas9 to unannotated genomic regions. Off-target cutting doesn't confound screen results. Short gRNAs have lower off-target cuts than full-length gRNAs.
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csRNP Tagging Diagram
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xCas9 directed evolution schematic

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