By Jennifer Tsang
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The vast majority of bacteria are undomesticated which limits the tools scientists can use to study them. For example, gene knockdown with CRISPR interference (CRISPRi) has been limited to lab-adapted bacteria because it has been challenging to introduce CRISPRi machinery into ...
In this quarterly blog series, we’ll highlight a few of the new CRISPR plasmids available at Addgene. We will still periodically focus on specific CRISPR plasmid tools more in-depth, but we hope that this blog series will help you find new CRISPR tools for your research.
Mutagenesis is a tool that both evolution and molecular biologists use to tinker with DNA. Making changes to a DNA sequence can help scientists identify and/or facilitate the evolution of new phenotypes, and forward genetics harnesses this at a large scale by screening diverse ...
This post was contributed by Greg Dingle, a software engineer with the Chan Zuckerberg Initiative. We hereby announce the general availability of new a tool for CRISPR scientists––CrispyCrunch! CrispyCrunch is a web app that helps scientists design and analyze batches of CRISPR ...
This post was contributed by Kutubuddin Molla, a Fulbright Visiting Scholar at the Pennsylvania State University. Imagine you are dealing with a defective gene, Xm, the sequence of which is identical to the correct gene, Xw, except for a single base. If you heard about CRISPR, ...
This post was contributed by Kelly Hills, founding bioethicist of Rogue Bioethics. On November 25, the MIT Technology Review dropped a bombshell report. A scientist working in China was using CRISPR/Cas9 in an attempt to create gene-edited babies. Several hours later, the ...
