CRISPR nucleases are remarkably precise molecular tools for cutting DNA. But “remarkably precise” does not mean “perfectly specific.” In reality, CRISPR nucleases occasionally make mistakes and cleave DNA sequences that only resemble the intended target. These unintended cuts ...
Deaminet 2026, held in Palm Springs in late January, brought together researchers studying deaminase enzymes across disciplines: from structural biologists resolving APOBEC proteins at atomic resolution, to cancer biologists dissecting mutational processes, to medical ...
This post was written by Professor Mark Howarth, investigator at the University of Cambridge. His research focuses on protein innovations for therapeutic and vaccine design. We all want tools that expand what we can achieve, but are simple to pick up and work well the first ...
Studying proteins in their natural context is one of the biggest challenges in biology. From tumor suppressors to growth factors, some of the most clinically-relevant proteins are also the hardest to study. One common strategy is protein overexpression — boosting levels so ...
This post was written by Abhi Aggarwal, from University of Calgary. Over the past few decades, genetically encoded calcium indicators (GECIs) have become a vital tool in neuroscience research. These fluorescent proteins light up in response to calcium, which is more than just ...
This blog post was written by Dr. Kutubuddin Molla, investigator at ICAR-Central National Rice Research Institute. When it comes to genome editing, CRISPR is a name that resonates with nearly every biologist, academic, and researcher. Among the most well-known CRISPR-associated ...
Lentiviral vectors have been a staple in molecular biology for over three decades. Widely used across various research applications, they have become indispensable tools for manipulating cells and organisms. They can be used for a variety of research purposes
One of the most pivotal decisions many PhDs face when transitioning from academia to industry is whether to stay hands-on in the lab or pivot to a managerial role. For those contemplating the leap into management, the journey can be as exciting as it is challenging.
