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The Many Reasons for Irreproducible Research- and a Vaccine to Eradicate It

Posted by Guest Blogger on Jan 30, 2020 9:15:00 AM

This post was contributed by David Mellor from the Center for Open Science.

In the last decade, researchers have brought issues in reproducible research to the forefront in the so-called “reproducibility crisis.” Results in preclinical, biomedical and psychological sciences were called into question after credible attempts to replicate major findings could not be replicated by other researchers.There is both theoretical and empirical evidence (in psychology, cancer biology, pre-clinical life science work, economics) that published research is difficult to replicate. 

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Topics: Scientific Sharing, Reproducibility

Developing a cold tolerant E. coli using specialized chaperones

Posted by Guest Blogger on Jan 28, 2020 9:35:41 AM

This post was contributed by Sreepadmanabh M, a member of the iGEM team from IISER Bhopal.

Following up its 2018 iGEM debut - centered around a prototypical methane biosensor - IISER Bhopal is back in the SynBio arena this year with a fresh team of twenty excited undergrads. Team IISER-B’s idea for the iGEM 2019 is to take bacteria out of their optimally suited temperature ranges and make them grow better at suboptimal ones, which could allow even your regular E. coli to thrive in the bitter cold. 

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Topics: Synthetic Biology, Other

The Open Repository of CRISPR Screens: CRISPR Screen Data in One Place

Posted by Guest Blogger on Jan 21, 2020 9:30:00 AM

This post was contributed by the Open Repository of CRISPR Screens.

Imagine you’ve just discovered that your favorite gene was described in a CRISPR screen publication. You see this mentioned in the results section, but you had to dig through the supplemental files to see the actual data. Now you’re wondering if your favorite gene is included in other CRISPR screens and whether that data is useful for your research. Fortunately, there’s a growing open repository of CRISPR screen data that might be able to help you out.

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Topics: CRISPR, Other CRISPR Tools

What Good Citizenship Can Do for Reproducibility in Science

Posted by Guest Blogger on Nov 7, 2019 9:18:13 AM

This post was contributed by Deborah Sweet, Vice President of Editorial at Cell Press.

Almost everyone who works in a lab struggles with reproducibility at some point.

Usually it comes up when a researcher decides on a new project and begins by trying to reproduce someone else’s result. Then, they hit trouble. The experiment won’t work. Even if it does, they don’t get the same result. So, then they end up investing time that they thought would be moving forward instead trying just to get going. It’s like being stuck in jail in Monopoly—you keep rolling the dice and not moving while all your friends are racing around the board. Eventually, you get lucky and manage to escape, but you’ve lost a lot of time.

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Topics: Scientific Sharing, Reproducibility, Scientific Publishing

FLEx Technology and Optogenetics: Flipping the switch on gene expression with high spatial and temporal resolution

Posted by Guest Blogger on Oct 17, 2019 8:28:58 AM

This post was contributed by Alessia Armezzani, scientific communication manager at genOway.

A few decades ago, the brain remained elusive, not from a lack of intellectual curiosity on the part of scientists but, rather, from the limited technologies available. Over the past few years, however, remarkable technological advances have taken researchers to the threshold of a revolution in modern neuroscience, an era in which technologies like FLEx and optogenetics meet, allowing scientists to investigate the fundamental basis of both brain function and dysfunction.

First, let’s start with the basics: What is optogenetics?

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Topics: Optogenetics, Other Plasmid Tools, Plasmids

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