Guest Blogger

Blog articles by Guest Blogger

Graphic showing a narrow range host plasmid with one ORI, and a broad range host plasmid with three ORIs with variable inserts.
a flow plot divided by a quadrant.
Graphic showing in vitro models for immunogenicity prediction of therapeutic antibodies
Schematic showing the X-CHIME approach.
Structure of a recombinant AAV vector, where two ITRs flank the gene cassette.
A cartoon of the cycle of an adenoviral particle. Beginning at the clathrin-coated pit, infecting virions are endocytosed and imported into the nucleus through steps of capsid disassembly endosomal membrane disruption, and dynein-dependent transport of the viral payload to nuclear pores via microtubules. It is a circular diagram going through time, with arrows between each of the steps. Many of the later steps are not mentioned here, but they regard manufacture of new virions, which does not happen with most viral vectors.
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