In this two-part series, we sit down to talk with two senior graduate students, Ben Vincent and Niroshi Senaratne, from the Biological and Biomedical Sciences program at Harvard University to get the scoop on the ups and down of graduate student life. Senior graduate students can sometimes be elusive or have a certain mystique that makes them difficult to approach for the youngster just starting in the lab, but they are exactly the people you should talk to if ruminating the trials and tribulations of the modern PhD program. Don’t be fooled! Most senior graduate students are friendly and full of useful advice. Stay tuned for concrete advice on how to pick a lab and a project.