If the fall colors are inspiring you to paint your cells in equally vivid colors, you'll want to check out the 34 new preps available in the Addgene viral vector repository! This includes the first Addgene prep packaged in the AAV9-X1.1 serotype.
In rodents, AAV9-X1.1 enables expression in brain endothelial cells via an injection into the systemic circulation. In Old World monkeys it actually targets neurons, and has 45-fold higher expression levels compared to AAV9. You can now target these cells with AAV-CAG-GFP packaged in AAV9-X1.1!
We also have eight new AAV-PHP.eB vectors from the Jonathan Ting lab at the Allen Institute, deposited as part of the BRAIN Armamentarium Collection. These preps drive expression of either Cre recombinase or a fluorescent marker in the various cell types of the basal ganglia. They work via newly-characterized enhancers that enable a whole host of (awesome) research not easily carried out before.
We have a bunch of other new AAV vectors as well — including next-generation biosensors for GABA, dopamine, serotonin, and much more. Check them out!
Table 1: New ready-to-use viral vectors in the Addgene repository
Looking for more viral vectors? Browse the full viral services collection or check out Addgene's Data Hub to see viral vector reports from other users. And don't forget to use the link below to keep up with the latest in Addgene's viral vector services and resources!
This blog post was written by Rachel Leeson and Brian O'Neill.
More resources on the Addgene blog
Topics: Viral Vectors, AAV, Addgene’s Viral Service
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