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To respond to environmental conditions, cells must be able to detect extracellular stimuli. One way they do so is through G protein-coupled receptors (GPCRs), receptors that play many roles in signaling processes including smell, taste, sight, inflammation, and ...
Originally published Sep 30, 2014 and last updated Dec 10, 2020 by Benoit Giquel. Adenoviral vectors (AdVs) have been used for many years for in vivo delivery and gene therapy and represent one of the most studied viruses. Adenoviruses are non-enveloped double-strand DNA viruses ...
This post was contributed by guest blogger, Leo Vo, a PhD candidate in the Sternberg Lab at Columbia University Medical Center. DNA transposons are ubiquitous genetic elements capable of spreading within and between genomes, and have been adapted for a wide variety of ...
Your next cool experiment requires some AAV. Where do you start? Plasmids of course! You just need three plasmids to start making the AAVs you need for your experiment: the packaging plasmid which contains the AAV structural and packaging genes, the adenoviral helper plasmid ...
This post was contributed by guest blogger, Rachel Rubinstein, a field-based software product manager at Oxford Nanopore Technologies. If the first thing you hear when someone says they’re a software product manager is “project manager,” you’re not alone. A few years ago when I ...
The Rett Syndrome Research Trust (RSRT) has an ambitious goal of curing Rett Syndrome and Addgene is thrilled to partner with them to launch a Rett Syndrome Plasmid Collection and Resource Center for Rett Syndrome research. With a shared passion for facilitating research and ...
Mark your calendars for November 16-20, 2020 for #DepositorWeek on Twitter! That’s today through Friday. There will be trivia, prizes, and more! We wanted to take a week to celebrate the scientists who make a big impact in open science. Depositors consistently contribute to our ...
