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The Many Reasons for Irreproducible Research- and a Vaccine to Eradicate It

Posted by Guest Blogger on Jan 30, 2020 9:15:00 AM

This post was contributed by David Mellor from the Center for Open Science.

In the last decade, researchers have brought issues in reproducible research to the forefront in the so-called “reproducibility crisis.” Results in preclinical, biomedical and psychological sciences were called into question after credible attempts to replicate major findings could not be replicated by other researchers.There is both theoretical and empirical evidence (in psychology, cancer biology, pre-clinical life science work, economics) that published research is difficult to replicate. 

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Topics: Scientific Sharing, Reproducibility

What Good Citizenship Can Do for Reproducibility in Science

Posted by Guest Blogger on Nov 7, 2019 9:18:13 AM

This post was contributed by Deborah Sweet, Vice President of Editorial at Cell Press.

Almost everyone who works in a lab struggles with reproducibility at some point.

Usually it comes up when a researcher decides on a new project and begins by trying to reproduce someone else’s result. Then, they hit trouble. The experiment won’t work. Even if it does, they don’t get the same result. So, then they end up investing time that they thought would be moving forward instead trying just to get going. It’s like being stuck in jail in Monopoly—you keep rolling the dice and not moving while all your friends are racing around the board. Eventually, you get lucky and manage to escape, but you’ve lost a lot of time.

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Topics: Scientific Sharing, Reproducibility, Scientific Publishing

Reproducibility for Everyone: Lessons from an Open Science Collaboration

Posted by Angela Abitua on Feb 28, 2019 8:34:05 AM

In 2017, Lenny Teytelman, CEO of protocols.io, organized a panel to discuss reproducibility issues in research. But he realized that it wasn’t enough to discuss the age-old problem of irreproducibility in science or even to discuss potential solutions. Despite all the talk, not much was being done to address the issue head on. It was at this pivotal moment that Teytelman realized that running interactive workshops to train researchers on tools and best practices could be an actionable way to tackle widespread irreproducibility. Luckily, there were other academics and like-minded organizations with similar ideas who were also thinking about reproducibility and shared similar desires to take action. Thanks to Teytelman’s vast network and ability to identify the right opportunities, he was able to bring together talented and motivated groups and individuals with similar ideas to actually do something about it.

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Topics: Scientific Sharing, Reproducibility

Unique and persistent IDs for improved reproducibility: Addgene now supports RRIDs and compact identifiers for all plasmids

Posted by Angela Abitua on Nov 20, 2018 3:17:00 PM

Have you ever found yourself frustrated reading through a paper to find that there is insufficient information about which reagents were used? Unambiguous identification of a reagent is crucial for reproducibility because mistakes in this can lead to wasted time or retractions.

Using a catalog number for identifying a reagent can be helpful, but it lacks context unless it links to a verified description of that reagent online. Furthermore, if the link between the catalog number and reagent description is lost (e.g. a supplier is bought out by another company and catalog number changes) the original identifier loses its meaning, making it difficult or impossible for researchers to track down that resource. A more long-term solution is the use of unique persistent identifiers (PIDs), a long-lasting way to identify and reference documents, files, or physical reagents.

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Topics: Scientific Sharing, Reproducibility

Replacing Paper: Tips for Choosing an Electronic lab Notebook

Posted by Guest Blogger on Jul 10, 2018 9:08:54 AM

This post was contributed by guest blogger, Tea Pavlek, Product Marketing Manager at sciNote.

Today, every lab has its own habits and approaches to record keeping. Top priorities in most cases include IP protection, publications and funding. If any of these three pillars crashes, the lab's success and the careers of its researchers are on the line.

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Topics: Scientific Sharing, Reproducibility

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