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The 10 Most Distributed Plasmid Technologies in Addgene's First 10 Years

Posted by Melina Fan on Jan 8, 2014 10:10:30 AM

Addgene was founded 10 years ago today. In that time, Addgene has shipped over 350,000 individual plasmids to 5,000 different research institutions. This has given us a unique window into technology trends in the life sciences.

In this post, we'll give you an inside look at the Top 10 plasmid technologies distributed through Addgene over our first 10 years.

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Topics: Plasmid Technology, Hot Plasmids, Scientific Sharing, Inside Addgene, Plasmid Kits

Using CRISPR/Cas9 to Edit Disease Out of the Genome

Posted by Kendall Morgan on Jan 7, 2014 10:45:00 AM

There can be no doubt that CRISPR/Cas9 technology has been a breakthrough for the genome-editing field. Now two studies reported in Cell Stem Cell last month show that this tool - already so useful in the laboratory - might also find its way to the clinic.

A team led by Jinsong Li from the Chinese Academy of Sciences found that mice with a dominant mutation in a gene that causes cataracts could be rescued by coinjection into zygotes of Cas9 mRNA and a single-guide RNA targeting the mutant allele. An independent team led by Hans Clevers at Hubrecht Institute in The Netherlands used the CRISPR/Cas9 genome editing system to correct the cystic fibrosis transmembrane conductor receptor (CFTR) by homologous recombination in cultured intestinal stem cells of patients with cystic fibrosis.

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Topics: Plasmid Technology, Genome Engineering, CRISPR

Three Tips to Organize Your Lab Notebooks in the New Year

Posted by Caroline LaManna on Jan 2, 2014 10:44:00 AM

Welcome to 2014! Get excited, it’s a new year. A time for resolutions: to wake up and get to the lab earlier, to read that stack of papers on your desk, and to tackle some new experiments before the next R01 is due. But what about organizing yourself and your lab? Organizing your lab notebooks, protocols, and to do lists can be easier than you think! Here are three tips to help you get organized and boost your productivity in 2014.

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Topics: Lab Tips

The Addgene Zoo - A Plasmid Repository with a Diverse Collection of Genes

Posted by Margo R. Monroe on Dec 31, 2013 9:50:50 AM

Over the past 10 years, Addgene has collected 30,000 plasmids contributed by over 1,700 research labs from around the world. These plasmids feature genes and expression systems from a variety of species beyond the human, mouse, bacterial, yeast, and zebrafish constructs commonly used in many labs. As more and more scientists contribute to Addgene’s library, the plasmid collection has started to resemble a large zoo filled with a diverse range of exotic animals. Let’s take a look at the some of the species represented in our collection.
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Topics: Fun

Top 10 Open Science Developments of 2013

Posted by Kendall Morgan on Dec 19, 2013 10:46:52 AM

It should come as no surprise that those of us at Addgene believe in the power of sharing, and especially in keeping the products of science accessible in one way or another to those who might be in a position to build on that work. That’s how science progresses after all, with each generation of scientists standing on the shoulders of their colleagues and all those who’ve gone before them. Given this interest in the ways science is shared and in making it easier to share, we take special note as the open science movement continues to gain traction.

One way to consider where the open access (OA) movement might be going is to consider some of the places it’s been. So, as 2013 comes to a close, let’s take a few minutes to reflect on some of the most noteworthy developments in open science this year. Here it goes, in no particular order, my top 10 open science developments, 2013 edition.

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Topics: Scientific Sharing

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