New Optogenetic Tools for Cytoskeleton and Membrane Control

By Mike Lacy

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Cartoon showing an experimental setup for using an optogenetic tool on a mouse neuron in an in vivo model.
bacteriograph of Michelangelo's
Electron micrograph showing hM4Di tagged with mCherry remaining cytoplasmic and hM4Di-HA tag localizes to the plasma membrane.
Graphic of channelrhodopsin activated with blue light. Without light, the channelrhodopsin is inactive, no ions flow in, and neurons don't fire. With blue light, the channelrhodopsin opens and allows an influx of ions into the neuron. This results in neuronal firing.
In blue light, OptoNanobodies cannot bind target protein. In darkness, OptoNanobodies bind the target.

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