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ReFigure: Save Scientific Figures into Dashboards and Share Your Insights

Posted by Guest Blogger on Dec 13, 2017 10:20:23 AM

This post was contributed by guest blogger Girija Goyal, cofounder of ReFigure.

Reading and exploration including replications and experiments resulting in “negative data” often dominate the early years of a project. Dissemination of the knowledge gained during this period occurs infrequently and rarely makes it into the small selection of data found in full-length publications. As early career researchers, we wondered how we could make the insights gained during this time more visible and thereby have a positive impact on science.

ReFigure saves time, knowledge and makes your insights discoverable. Watch this quick video to learn how ReFigure works and continue reading for more details.

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Topics: Scientific Sharing

New CRISPR Web Resources and #12DaysofCRISPR Recap

Posted by Mary Gearing on Dec 12, 2017 10:13:34 AM

Since the start of the CRISPR revolution, Addgene has distributed over 100,000 CRISPR plasmids. But that’s not our only job - we strive to also give you high-quality educational resources to help you do better research. CRISPR is an incredibly fast-moving field, and we want to make it easy for you to keep up with new developments (and, of course, find plasmids that will be useful to you.)

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Topics: CRISPR, CRISPR 101, Using Addgene's Website

Hot Plasmids Episode 4: B. subtilis Libraries, iPSC Reprogramming, CRISPR Tools, & More!

Posted by Tyler Ford on Dec 11, 2017 9:02:49 AM

In the fourth episode of our Hot Plasmids podcast series, you'll learn about new libraries for studying B. subtilis biology, plasmids for enhancing iPSC production, and CRISPR tools for plants. You can find additional hot plasmids in our quarterly newsletter or on our hot plasmids webpage.

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Topics: Hot Plasmids, Optogenetics, CRISPR, Podcast

CAPTURE-ing Chromatin Interactions: Using CRISPR-dCas9 to Study Gene Regulation

Posted by Beth Kenkel on Dec 7, 2017 9:16:43 AM

Plasmids can be amazing and simple tools for studying gene regulation. They are used to study how transcription factors and other trans-regulatory elements (TREs) and some cis-regulatory elements (CREs), like promoters, influence gene expression. However, scientists frequently return to native chromosomes because chromatin context matters. The impact of TREs and CREs on gene expression is commonly investigated via Chromatin Immunoprecipitation (ChIP) and chromatin capture techniques, respectively, but these two separate methods are not without their own technical challenges. Enter the Xu Lab's CAPTURE, a method for identifying TREs and CREs that partners CRISPR’s targeting abilities with the strength of the biotin-streptavidin interaction. CAPTURE is capable of identifying old and new TREs and CREs, CRE-CRE interactions, and has even provided enough data for Liu et al to re-draw the beta-globin locus regulation model. Read on to learn more about this captivating tool!

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Topics: CRISPR, Techniques

Transferable Skills Guide: Time Management

Posted by Tyler Ford on Dec 5, 2017 8:52:56 AM

A recent survey of PhDs found that many researchers feel that they lack formal training in a variety of transferable skills. At Addgene we've set out to fill this gap by both highlighting that researchers do learn MANY transferable skills while working in the lab and by offering advice on areas where you might need some help. Today in our transferable skills guide: Time Mangement for Scientists.

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Topics: Career, Career Readiness, Transferable Skills Guide

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