Integrins are essential cell surface receptors involved in complex signaling pathways and the linkage of intra- and extracellular environments. Found on nearly every cell in the human body, integrins are key to a diverse array of processes, including cell adhesion, migration, ...
Monoclonal antibody drugs are popular therapeutics for a plethora of disease conditions, from cancer to autoimmune disorders. Antibodies administered as drugs are still immunogenic, meaning that they elicit an immune response from the body. Several factors contribute to the ...
Addgene is excited to announce the launch of our partnership with the Institute for Protein Innovation (IPI). Together, we’ll be working to provide researchers with a collection of IPI’s well-validated and ready-to-use recombinant antibodies. The first collection, a set of ...
It’s not just the antibodies that matter when you’re prepping for your experiment - there are a number of outside factors that need to be considered as well. In this post, we’ll touch on antibody storage, buffer considerations, and give just the lightest of nods towards ...
If you work in a lab that regularly does immunoimaging, there’s likely a large collection of antibodies in your lab. Perhaps you’re even in that mythical place where antibodies are well-organized, documented, and easy to find (though we might need to see it to believe it.) As ...
If you’ve been following our antibody blog posts, then you likely already have a good idea of the basics of immunoimaging. A scientist conjugates an antibody with a signaling molecule, the antibody binds to a protein, and then voila! Wherever your protein of interest is, a ...
There are a lot of ways to classify antibodies: monoclonal, polyclonal, scFvs, nanobodies, and the list goes on. But have you heard of an antibody isotype? An isotype determines several key characteristics of an antibody as well as the role it plays in an immune response. But ...
It’s time to choose your own protein purification adventure. You want to purify your favorite protein (YFP). You have two options: Option #1: Affinity tag purification You tag YFP and use an affinity column for purification. After binding YFP to the column, you wash several ...
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