Master plasmid fundamentals, CRISPR techniques, AAV serotype selection, and antibody applications. Written by scientists, for scientists.
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All organisms share an innate goal to survive. This past year, scientists hijacked survival tactics of prokaryotes to deliver the technological biological blockbuster known as the CRISPR (clustered regularly interspaced palindromic repeats) Cas (CRISPR associated genes) system. ...
When neuroscience graduate student Silvana Konermann first entered Feng Zhang’s lab at MIT, the use of customizable DNA-binding domains based on transcription-activator-like effectors (TALEs) as anchors for genome engineering applications was still very new. Now, Konermann and ...
Homologous recombination is the process by which nearly all domains of life repair genomic damage, specifically double strand breaks. Researchers have long taken advantage of this natural process to integrate protein tags into the genomes of S. cerevisiae and S. pombe. The ...
When I got the job of Outreach Scientist at Addgene, my first thought was “I get to talk to scientists from around the world making breakthrough discoveries!” I knew right then I had found my dream job, because one thing I learned in grad school was that scientists have amazing ...
