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How Exercise Purges Stress and Keeps Depression at Bay

Posted by Kendall Morgan on Nov 25, 2014 11:02:00 AM

It’s well known that exercise can help fight stress and depression, and now researchers have reported a mechanism based on studies of transgenic mice that helps to explain how it works. The findings in a recent issue of Cell demonstrate how PGC-1a1, a transcriptional coactivator induced in skeletal muscle by exercise and endurance, protects the brain from depression.

Mice that are genetically modified to produce extra PGC-1a1 only in their skeletal muscle show resistance to stressful circumstances – including unpredictable loud noises and flashing lights - that sent average, control mice into depression. In case you were wondering, depression shows up in mice as poorer performance on forced swim tests and less interest in sweets.

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Topics: Hot Plasmids, News

We've Launched Addgene's New & Improved Website!

Posted by Caroline LaManna on Nov 19, 2014 10:10:53 AM

We have lift off! You may have noticed a new friendly face on our website this morning announcing the launch of our new website. We are excited to finally bring you our new and improved website. We’ve been working diligently over the past month to design a site that is easier to navigate and helps you more effectively find the plasmids (and plasmid cloning information) that you’re looking for. 

I’ve put together a few screenshots below to show you just some of our new features, but the best way for you to see what’s changed is to head over to the upgraded Addgene website and explore for yourself. Don’t worry – it’s the same URL you’ve been using for years, so I promise you won’t get lost!

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Topics: Inside Addgene, News

A Scientist's Guide to Ebola

Posted by Kendall Morgan on Oct 16, 2014 11:01:00 AM

It’s pretty hard to escape news and fears of Ebola these days, as the infectious disease once limited to small pockets in Africa has spread to urban areas and across the ocean. A nurse in Dallas was the first to be infected in the United States while caring for a patient, despite wearing protective gear, and now comes news of a second Texas healthcare worker with symptoms. The World Health Organization says the number of new cases could rise to 10,000 a week within two months.

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Topics: News

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