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Oh, The Places You Can Go: Careers in Science Communication - Product Management

Posted by Beth Kenkel on Nov 1, 2017 10:04:15 AM

In this post of the Careers in Science Communication blog series, you’ll hear more about Caitlin Runne-Janczy and her job as a Subject Matter Expert/ Product Development Manager at eScience Labs. To learn how Caitlin got into scicomm and landed her first post-grad school job, head over to part I of the interview.

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Topics: Cancer, SciComm Careers

In Memoriam - The Origins of pBABE and Generations of Cancer Research

Posted by Guest Blogger on Sep 29, 2017 12:44:40 PM

This post was contributed by guest blogger, Jay P. Morgenstern,  Ph.D., Director, Genetic Engineering & Molecular Biology at Warp Drive Bio. The post is in memoriam of his late father and pBABE’s namesake, Harold (Babe) Morgenstern.

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Topics: Hot Plasmids, Cancer

Cancer, Inflammation and Immunity - Harnessing the Body’s Defenses to Fight Cancer

Posted by Susanna Bachle on Jul 6, 2017 9:59:43 AM

Research tackling questions in the fields of Cancer, Inflammation and Immunity, as well as various combinations thereof (so called “Immuno-Oncology”) is exploding. Researchers are increasingly able to harness the body’s immune system to fight progressing cancers. It was inspiring to participate in the 2017 Cell Symposium on Cancer, Inflammation and Immunity and learn more about “... recent findings in basic immunology, cancer-immune cell interactions, cancer immunotherapy, as well as new approaches to reprogramming tumor-associated inflammation for therapeutic benefit ”as stated by the organizers.

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Topics: Cancer

Enabling Precision Functional Genomics with the Target Accelerator Plasmid Collection

Posted by Guest Blogger on May 11, 2017 10:30:00 AM

This post was contributed  by Jesse S. Boehm, the Associate Director of the Cancer Program at the Broad Institute of Harvard and MIT.

The notion of cancer precision medicine seems so simple! Take a patient’s tumor sample, use cutting edge genomic technologies to map the mutations that are present, and use prior knowledge (data connecting each genotype with vulnerabilities) to design a therapeutic strategy that works.

But, those darn cancers have revealed many tricks up their sleeves and most patients still don’t benefit from this approach. One central bottleneck is that most recurrently mutated cancer genes are rare and most of the individual variants found in tumors are exceedingly rare. As a result, how most of these “variants of unknown significance” (sometimes called “VUS”) function is unknown. How can we make a decision for each patient if the majority of information on each cancer clinical sequencing report includes rare variants that haven’t been characterized?

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Topics: Cancer

Cancer and the Immune System: Deciphering the Relationship

Posted by Guest Blogger on Mar 14, 2017 10:30:00 AM

This post was contributed by guest blogger Subhadra Jayaraman, a doctoral candidate at Binghamton University

Cancer is one of the greatest examples of survival of the fittest. Cancer cells find a way to grow haywire, access and create more vasculature to feed themselves, use the blood stream to commute to and invade multiple organs, and most importantly escape the immune mechanisms of the host. The cause, manifestation, diagnosis, recurrence, and treatment of cancer have been extensively explored. Biologists have attempted to study cancer from every possible angle to leave no stone unturned, but cancer has been producing landslide after landslide, only adding more stones to the field.

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Topics: Cancer

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